People grappling with terminal illnesses often experience severe emotional distress, including depression, anxiety, existential dread, and a feeling of aimlessness. This emotional weight can further complicate their already challenging circumstances.
While traditional methods such as counselling and cognitive-behavioural therapy (CBT) can provide relief, their effectiveness varies from person to person. Consequently, researchers are seeking innovative and alternative approaches for end-of-life care.
There’s a growing body of research suggesting that psychedelic therapy could potentially alleviate existential distress in patients diagnosed with incurable diseases. A review in Neuropsychopharmacol Biol Psychiatry indicates that psychedelics may help reduce depression and anxiety symptoms, improve quality of life, and alleviate fear associated with death in patients with life-threatening conditions.
In an effort to delve deeper into the potential benefits of psilocybin mushrooms, many Canadians buy shrooms online for investigational purposes.
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Psilocybin’s Impact on the Brain
The National Institutes of Health characterizes psychedelics derived from shrooms as potent substances that can alter cognition. They affect mood and perception by interacting with the brain’s serotonin circuits.
Here’s what various studies have to say:
| Researchers | Findings |
| Department of Psychiatry and Behavioral Sciences, University of Texas | Psychedelics such as psilocybin interact with the brain’s serotonin 2A receptors, which regulate emotions and perception. |
| Mental Health News Study | Psilocybin, a natural hallucinogenic compound present in over 200 species of fungi, could potentially reconfigure the brain’s wiring in people with depression, potentially paving the way for a cure. |
| Researchers from UC San Francisco and Imperial College London | Psilocybin bolsters connections between different brain regions in people with depression, which could aid them in breaking free from excessive self-reflection and rumination. |
| A randomized, double-blind trial by John Hopkins University | Large doses of psilocybin significantly reduced depression, anxiety, and fear of death, while improving life quality, sense of life’s meaning, and optimism. |
| Clinical trial from New York University | Between 60% and 80% of participants noted a decrease in anxiety and depression after undergoing psilocybin therapy, which subsequently led to the reduction of existential distress. The study further noted that the therapeutic benefits were associated with the psychedelic experience triggered by psilocybin. |
Investigative Study
Researchers from the UCSF Weill Institute for Neurosciences conducted 2 studies involving 60 participants, all of whom underwent fMRI brain scans.
Study Approach
- First Study. The study involved participants who were battling treatment-resistant depression. All participants received a dosage of psilocybin.
- Second Study. The participants, who had less severe depression, were not made aware if they were given psilocybin or an antidepressant placebo (escitalopram). They also participated in the same psychotherapy treatment.
Brain scans were performed before and after the treatment to assess the effects.
Study Conclusions
- Psilocybin therapy reduced the connections within brain regions related to depression, including the default mode, salience, and executive networks. Additionally, it increased connections to less integrated brain areas.
- The therapy minimized the effects of emotional avoidance and significantly improved cognitive functioning.
The influence of psilocybin on brain rewiring was observed to last up to three weeks after the second dose. Therefore, psilocybin represents a potential alternative cure for depression by reconfiguring the brain and reducing persistent negative thought patterns associated with the disorder. This result suggests that psilocybin operates differently from conventional antidepressants.
Psilocybin Therapy – An Emerging Treatment Option
Psilocybin therapy involves the controlled administration of psilocybin in a therapeutic setting, usually combined with psychological support. This approach is increasingly being recognized for its potential to treat cases of treatment-resistant depression, anxiety, and existential distress among terminally ill patients.
Recently, a survey was conducted by researchers from Université Laval’s Faculty of Pharmacy, McGill University, Université de Montréal, and UQAR to gauge public opinion on the medical use of psilocybin for end-of-life care. According to the survey published in Palliative Medicine, almost 4
One in every five Canadians supports the use of psilocybin for mitigating existential distress near the end of life.
The lead researcher, Michel Dorval, noted that studies have shown that psilocybin, when paired with psychotherapy, can provide quick, strong, and lasting relief for individuals grappling with advanced cancer. Importantly, psilocybin therapy can trigger a deep sense of comprehension and solace that can persist for up to six months.
Additionally, the survey indicates greater support from those with palliative care experience or prior use of psilocybin. Dorval suggests that personal encounters with end-of-life distress could contribute to this open-mindedness towards innovative treatments.
Despite the prevalent prejudices against psychedelic drugs, the research reveals a growing acceptance of psilocybin therapy in Canada, particularly in palliative and end-of-life care contexts. The authors believe these findings will improve the availability of this breakthrough therapy.
Additional Benefits of Psilocybin Therapy
1. Treatment for Alcohol Use Disorder
In a double-blind, randomized trial featuring 93 participants, published in JAMA Psychiatry in August 2022, it was demonstrated that the combination of psilocybin and psychotherapy resulted in significantly fewer instances of heavy drinking over approximately eight months compared with a control group receiving placebo therapy. Moreover, the group treated with psilocybin consumed less alcohol on the days they chose to drink.
2. Aid in Smoking Cessation
Although it’s notoriously difficult to quit smoking, a small pilot study by researchers at Johns Hopkins University, published in The American Journal of Drug and Alcohol Abuse in January 2017, suggested that psilocybin, in combination with cognitive behavioural therapy (CBT), helped 10 out of 15 participants stay smoke-free for a year. A subsequent study suggested that the psychedelic experience could potentially reshape a smoker’s identity, thus encouraging long-term abstention from smoking.
3. Remedy for Anorexia
New research indicates that psilocybin could be helpful for individuals battling anorexia. A preliminary study conducted in May 2022 and published in Biological Psychiatry reported significant symptom reduction in eating disorders and anxiety among adults with anorexia who underwent psilocybin-supported psychotherapy.
4. Alleviation of End-of-Life Anxiety
Terminal illness often brings with it an overwhelming sense of anxiety and depression. Psilocybin therapy presents a glimmer of hope, as it has shown potential in easing these distressing symptoms. Studies have demonstrated considerable reductions in depression and anxiety among patients facing life-threatening cancer diagnoses, following their engagement with psilocybin therapy.
What to Expect from Psilocybin Therapy?
Psilocybin therapy can be a transformative experience. Our therapy sessions are designed to offer prompt and potent healing results that could yield enduring benefits. Each session is personalized to cater to individual needs, adhering to precise clinic or trial protocols.
| Phase | Description | Duration |
| Before | The preliminary sessions are dedicated to discussing any apprehensions and treatment goals with a facilitator, fostering a sturdy bond and a secure environment. | 1 to 6 hours |
| During | The participant ingests a dose of psilocybin in a serene setting, lying down with an eye mask on, listening to a pre-selected playlist, under the supervision of a therapist. | 5 to 8 hours |
| After | Subsequent sessions serve as a platform to deconstruct the experience with the therapist, which aids in integrating the gained insights into everyday life. | Several sessions spanning hours |
How to Approach Psilocybin Therapy?
- Find clinics where psilocybin is legal and if necessary, consider joining a waiting list.
- Select a clinic that offers psilocybin treatment under the supervision of a therapist or a professional guide to ensure a therapeutic experience.
- Interview potential therapists regarding their credentials, experience, therapeutic approach, and proficiency in managing mental health conditions.
- Be open about your motivations for seeking treatment, your mental health status, medical history, and any family history of mental health disorders.
- Consider therapists who specialize in your particular mental health condition and seek advice and training from organizations like the Psilocybin Assisted Therapy Association (PATA).
- Disclose your comprehensive medical and mental health history, especially if there is a family history of schizophrenia or psychosis.
- Discuss your decision to undertake psilocybin therapy with your current mental health provider and inquire if they are willing to collaborate with your psilocybin therapy team.
- Talk about the dosage, protocol, and the need to start For those who are new to psilocybin therapy, it’s advisable to start with smaller doses under the supervision of your psilocybin therapist to ensure safety.
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Frequently Asked Questions
Who would be suitable for psilocybin therapy?
If you are dealing with depression, anorexia, alcohol addiction, trying to quit smoking, or facing a life-threatening disease, psilocybin therapy might be worth considering.
However, if you or your family have a history of schizophrenia or psychosis, hallucinogens like psilocybin could exacerbate your symptoms. The same applies to those with bipolar disorder or borderline personality disorder, who are generally advised against using these substances.
What is the usual dosage of psilocybin for therapy?
The dosage generally changes, often starting with smaller doses in a therapeutic environment and adjusting according to individual responses. Clinical studies have shown that a single 25-milligram dose of synthetic psilocybin, given alongside psychological support, led to a reduction in depression scores in patients with treatment-resistant depression.
Can psilocybin be used to treat PTSD?
This area of study is developing quickly. However, the research on MDMA, an unconventional psychedelic with stimulant properties used in conjunction with psychotherapy for PTSD treatment, is more developed. Studies on this psychedelic have advanced to phase 3 clinical trials, and it is expected that MDMA could be approved for PTSD treatment in the near future.
